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KMID : 0614620000360050614
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Korean Journal of Gastroenterology
2000 Volume.36 No. 5 p.614 ~ p.621
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Cisplatin-Induced Peripheral Neuropathy in Patients with Advanced Gastric Cancer
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Kim Jong-Gwang
Ryoo Baek-Yeol
Park Yeon-Hee
Kim Bong-Seog
Choi Seong-Jun
Kim Tae-You
Yoo Sung-Jae
Jung Sook-Hyang
Han Chul-Ju
Kim You-Cheoul
Kim Chang-Min
Lee Jhin-Oh
Kang Yoon-Koo
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Abstract
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Background/Aims : Since cisplatin was widely used for the treatment of advanced gastric cancer, prevention and management of its side effects have become an important issue. Among the various side effects, neurotoxicity still remains as the major dose-limiting side effect of cisplatin. To investigate the frequency and the prognostic factors of neurotoxicity associated with cisplatin-containing chemotherapy, we performed this retrospective analysis.
Methods : We analyzed clinical data of 317 patients with advanced gastric cancer treated with cisplatin-containing (20 mg/m2/day, D1-5 per cycle) chemotherapy in Korea Cancer Center Hospital from 1992 to 1996.
Results : Peripheral neuropathy was developed in 44 patients(13.9％; 95％ C.I, 10-17.8％): 28 patients in who grade I and 16 patients in who grade Ⅱ. The incidence of peripheral neuropathy was increased as the cumulative dose of cisplatin increased. Age(p=0.0458) and cumulative dose of cisplatin(p〈0.0001) were significant prognostic factors for the development of peripheral neuropathy in multivariate analysis.
Conclusions : Peripheral neuropathy was a side effect of cisplatin-containing chemotherapy observed frequently in patients with advanced gastric cancer. Its development was closely related with cumulative cisplatin dose and patient’s age. Once peripheral neuropathy developed clinically, it did not improve in most patients even after the administration cisplatin was discontinued.
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KEYWORD
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Cisplatin, Peripheral neuropathy, Advanced gastric cancer, Cisplatin
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